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apalutamide will lessen the level or effect of diazepam by impacting hepatic enzyme CYP2C19 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a robust CYP2C19 inducer, with medication which can be CYP2C19 substrates can result in lower exposure to these medications.Monitor Intently (1)crofelemer increases levels of diazepa